| # | Children | Name | Born | Died | Father | Mother |
| 1 | | | b. 19 Aug 1515 | d. 21 Sep 1518 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 2 | | | b. 22 Nov 1515 | d. 11 Jun 1560 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 3 | | | b. 23 Oct 1516 | d. 18 Sep 1524 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 4 | | | b. Abt 1518 | d. 1580 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 5 | | | b. 28 Feb 1518 | d. 10 Aug 1536 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 6 | | | b. 28 Feb 1518 | d. 10 Aug 1536 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 7 | | | b. 31 March 1519 | d. 10 July 1559 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 8 | | | b. 10 Aug 1520 | d. 7 Jul 1537 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 9 | | | b. 22 Jan 1522 | d. 09 Sep 1545 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 10 | | | b. 20 Jun 1523 | d. 15 Sep 1574 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |
| 11 | | | b. 20 Jul 1524 | d. 1525 | Francis I (Capetian Dynasty House of Valois), Count of Provence Angouleme, Duke of Brittany, King of France The Father and Restorer of Letters | Claude "The Good" 1499, Duchess Of Brittany, Queen Of France |