| Children |
| | 1. James Stewart, Duke of Rothesay , b. 21 Feb 1507, Holyrood Palace d. 27 Feb 1508, Stirling Castle (Age 1 year) |
| | 2. Unnamed Daughter Stewart, b. 15 Jul 1508, Holyrood Palace d. Aft. 15 Jul 1508, Holyrood Palace (Age 0 years) |
| | 3. Arthur Stewart, Duke of Rothesay, b. 20 Oct 1509, Holyrood Palace d. 14 July 1510, Edinburgh Castle (Age 0 years) |
| | 4. James V Stewart, King of Scotland, b. 10 Apr 1512, Linlithgow Palace, Linlithgow, West Lothian, Scotland d. 14 Dec 1542, Falkland Palace, Fife, Scotland. Buried Holyrood Abbey, Edinburgh, Scotland (Age 30 years) |
| | 5. unnamed daughter Stewart, b. Nov 1512, Holyrood Palace d. Nov 1512, Holyrood Palace. (Age 0 years) |
| | 6. Alexander Stewart, Duke of Ross, b. 30 Apr 1514, Stirling Castle d. 18 Dec 1515, Stirling Castle (Age 1 year) |
|