| # | Children | Name | Born | Died | Father | Mother |
| 1 | | | b. Abt. Dec 1325 | d. 11 Apr 1408 | Hugh le Despenser, 1st Baron Despenser | Eleanor de Clare, suo jure 6th Lady of Glamorgan - Countess of Hertford and Gloucester |
| 2 | | | b. 22 Sep 1373 | d. 13 Jan 1400 | Edward le Despenser, 1st Baron Despenser (2nd creation) KG | Elizabeth Burghersh, 3rd Baroness Burghersh |
| 3 | | | | d. 3 Nov 1415 | Edward le Despenser, 1st Baron Despenser (2nd creation) KG | Elizabeth Burghersh, 3rd Baroness Burghersh |
| 4 | | | | | Edward le Despenser, 1st Baron Despenser (2nd creation) KG | Elizabeth Burghersh, 3rd Baroness Burghersh |
| 5 | | | | | Edward le Despenser, 1st Baron Despenser (2nd creation) KG | Elizabeth Burghersh, 3rd Baroness Burghersh |
| 6 | | | | d. 30 Oct 1426 | Edward le Despenser, 1st Baron Despenser (2nd creation) KG | Elizabeth Burghersh, 3rd Baroness Burghersh |